Function of LMP2B in EBV-positive Burkitt's Lymphoma, Fachbücher von Markus Rechsteiner
Epstein-Barr virus (EBV) is a human -herpesvirus that persists latently in the memory B-cell pool. EBV is linked to malignanc... Mehr erfahren
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Epstein-Barr virus (EBV) is a human -herpesvirus that persists latently in the memory B-cell pool. EBV is linked to malignancies including Burkitt's lymphoma (BL) where it expresses specific latency genes. Among these genes, latent membrane protein (LMP)2A and LMP2B seem to be involved in the regulation of EBV latency. LMP2A blocks B-cell receptor (BCR) signalling after its engagement, which activates as well lytic EBV infection. Therefore, LMP2A contributes to the persistence of EBV. By contrast, the function of LMP2B, a splice variant of LMP2A, is still not resolved. The experimental setup presented in this book revealed for the first time that silencing of LMP2B resulted in reduced expression of lytic EBV mRNA and proteins upon BCR cross-linking. By contrast, overexpression of LMP2B resulted in the opposite. We could further demonstrate that LMP2A and LMP2B physically interact and tha.
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Lieferzeit:2-4 Werktage
Marke:Südwestdeutscher