KLF2, a master regulator of peripheral B lymphocyte homeostasis, Fachbücher von Rebecca Winkelmann
Lymphocytes play a prominent role in the combat of infectious diseases. For a sufficient but limited immune response it is es... Mehr erfahren
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Lymphocytes play a prominent role in the combat of infectious diseases. For a sufficient but limited immune response it is essential that migration and activation of lymphocytes are strictly controlled. The transcription factor KLF2 modulates T lymphocyte egress from lymphoid organs by regulating S1P1. This is not the case for B cells. Instead, KLF2 regulates homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of 7 integrin. In mice with a B cell-specific deletion of KLF2, S1P1 expression on B cells was only slightly affected. Accordingly, all splenic B cell subsets were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. In contrast, fewer peyers patches harboring less B cells, fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bo.
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Lieferzeit:2-4 Werktage
Marke:Südwestdeutscher